The quest for legendary gear in Borderlands 2 often leads Vault Hunters down specific farming paths to optimize their weapon arsenals. Among the most iconic items available is the Infinity Pistol, a legendary Vladof sidearm celebrated for its infinite ammunition gimmick and unique cross-shaped firing pattern. Acquiring this highly coveted weapon requires understanding the specific drop sources and execution strategies that make the farming process efficient.

Unlocking the Medical Mystery Mission

Before players can reliably hunt down the primary source of the Infinity Pistol, they must complete a crucial side quest in the campaign. Vault Hunters need to visit Dr. Zed in Sanctuary to accept the Medical Mystery mission, which directs them to investigate strange weapon anomalies. Fulfilling this quest line permanently unlocks the required boss spawn within Three Horns Valley, opening the door for repeated encounters.

It is also highly recommended to complete the neighboring quest titled No Vacancy to activate the local fast travel station. Having this nearby travel point functioning properly minimizes travel time during consecutive gaming sessions. Streamlining your initial route ensures that you spend less time running across the map and more time actively engaged in combat.

Conquering Doc Mercy in Three Horns Valley

The absolute best method for securing the Infinity Pistol is repeatedly defeating the specialized mini-boss known as Doc Mercy. Located inside a cavernous bandit camp in Three Horns Valley, this enemy carries the weapon as a designated dropship reward. Players can rapidly reach his domain by utilizing local geographic geometry, such as launching their characters via strategic steam vents to bypass minor encounters.

Upon arriving at his perch, Vault Hunters must quickly eliminate Doc Mercy while keeping a close eye on his immediate surroundings. Because legendary loot can occasionally clip through the environment or tumble off the elevated platforms, searching the floor thoroughly after each kill is essential. If the pistol does not drop on the initial attempt, players can simply save and quit to immediately reset the encounter.

Optimizing Part Layouts and Character Synergy

Maximizing the combat efficiency of your newly acquired pistol requires a basic understanding of weapon components and character skills. A perfect version of this legendary firearm typically features a matching Vladof grip alongside the highly coveted Vengeful prefix, which drastically increases the base fire rate. Elevating the fire rate is critical because it forces the infinity spray pattern to reset faster, yielding significantly higher overall damage output.

Certain Vault Hunters can exploit the weapon's unique mechanics to achieve devastating results during endgame challenges. For instance, Zer0 features a specialized skill called One Shot One Kill that grants a permanent damage boost because the magazine is perpetually considered full. Conversely, players utilizing Gaige must exercise caution as certain Anarchy mechanics can accidentally reduce the weapon's magazine capacity to zero, rendering it entirely unusable.